The study found that by manipulating the activity of Activin receptors — receptors found in the brain — the researchers were able to increase or decrease cocaine-taking and relapse behavior in animal models. The study focused, specifically, on Activin receptors in regions of the brain that are involved in pleasure and reward.“There are changes in the brain caused by drug use that occur and persist, but are only unmasked after withdrawal from a drug — in this case, cocaine,” Dietz says. “Cocaine use alters the connections between certain neurons through changes in the shape of the cells.”The researchers discovered that the Activin pathway controls the ability of cocaine to induce this change in the neurons and determined that the Activin receptor may control this response to cocaine by regulating the expression of a number of genes.“Understanding this critical pathway will help us pursue new directions in potential pharmacological and gene therapies to prevent drug relapses,” Dietz says. “If we can control this pathway, we may be able to help prevent relapses in people who have been abstinent from cocaine.” Share on Facebook Pinterest Share LinkedIn Email Share on Twitter Researchers at the University at Buffalo have discovered a previously unknown neural pathway that can regulate changes made in the brain due to cocaine use, providing new insight into the molecular basis of cocaine addiction.“Addiction is a life-long affliction manifested by episodes of relapse, despite prolonged abstinence,” says Amy Gancarz, PhD, lead author of the study, which was published on June 1 in an Advance Online Publication in Nature Neuroscience. “There is a need to more fully understand the long-term molecular changes in the brain involved in drug craving and relapse.”Gancarz, a former postdoctoral associate with the UB Research Institute on Addictions (RIA), worked on the study under the direction of senior author David Dietz, PhD, assistant professor in the Department of Pharmacology and Toxicology in UB’s School of Medicine and Biomedical Sciences. Dietz is also a faculty member in UB’s Neuroscience Program and an affiliated scientist with RIA.
On the job in Los Alamos Monday for lunch in at Time Out Pizzeria is Ramona Salaiz creating one of the specialty pizzas offered at the eatery. Time Out Pizzeria at 157 Central Park Square is open 11 a.m. to 3 p.m. Monday, 11 a.m. to 7 p.m. Tuesday through Friday 3-7 p.m. Saturday and closed Sunday. For information, call 505.662.7261 or visit www.timeout4pizza.com. #worklosalamos #wherediscoveriesaremade. Photo by Jenn Bartram/ladailypost.com
Siem Offshore, a Norwegian offshore vessel provider, has received approvals from banks for a restructuring plan.The company said the new financial platform would position the company for the expected challenging market in the coming years.According to Siem Offshore, the approvals include a three-year extension of the final bullet payments of all mortgage debt due before December 31, 2019, deferral of instalments for the fleet of AHTS vessels for 2.5 years with a cash sweep mechanism, as well as easing of certain covenant requirements to the company’s banks for the next three years.Payment of interest and installment on all bank debt except for debt related to AHTS vessels will continue as normal. The agreement is conditional on a restructuring of the Company’s two public bonds, Sie.It is further agreed, Siem said, to establish a stand-alone AHTS vessel company, Siem AHTS Pool AS ( SAP), where Siem Offshore Inc. through its subsidiary Siem Offshore Rederi AS has sold all its 8 AHTS vessels, and the pool partner Singa Star PTE LTD has sold 2 AHTS vessels to SAP.All vessels have in the past been operated in a pool agreement between Siem Offshore and Singa Star. Post the transaction, Siem Offshore and Singa Star will hold shares in SAP in proportion to the net value of the vessels transferred to SAP, representing a share for Siem Offshore of 78.16% and Singa Star of 21.84%.
Performance was in line with expectations and the company took advantage of a calmer market to accelerate its maintenance program for 2010. As a result, Dockwise is well prepared for an upswing as the year progresses, said André Goedée, the CEO of Dockwise. The company recorded a loss of USD3.2 million, down from a USD27.3 million profit in the same period last year. Revenues for the quarter totaled USD95.2 million down from USD127.2million in the same period last year. Goedée added: “Encouragingly, the first quarter saw increased tendering activity, and a corresponding improvement in long range visibility in our markets. Our strategic view of the industry has been confirmed by the emergence of a new set of major scale float-over and deepwater projects for execution beyond 2012. Dockwise has leadership in this premium market, where we intend to maintain and grow our presence.”
Related PARRAMATTA, NSW – FEBRUARY 01: Kenya before the game during Pool A, Match 7 between Kenya and Fiji at the HSBC Sydney Sevens Rugby on February 01, 2020 at Bankwest Stadium in Sydney, Australia. (Photo by Speed Media/Icon Sportswire via Getty Images) Kenya before the game during Pool A, Match 7 between Kenya and Fiji at the HSBC Sydney Sevens Rugby on February 01, 2020 at Bankwest Stadium in Sydney, Australia. (Photo by Speed Media/Icon Sportswire via Getty Images)Kenya Sevens head coach Paul Feeney made five changes to the squad that will play in the North American leg of the HSBC World Rugby Sevens Series.Former Shujaa captain Oscar Ouma, Sammy Oliech, Jacob Ojee, Daniel Sikuta and Oscar Dennis have been drafted into the side for the legs in Los Angeles, USA, and Vancouver, Canada.Ouma and Oliech have not played for Shujaa since the 2017/2018 season while Ojee, Sikuta and Dennis did not play in the Oceania legs in Hamilton and Sydney. The trio did not feature either due to injury or squad rotation.Bush Mwale, Geoffrey Okwach, Herman Humwa, Johnstone Olindi and Nelson Oyoo have been omitted from the squad to North America.Feeney said the changes to the squad were exciting and offered other players an opportunity to perform.“Plenty of changes but lots of old heads coming in with the changes and we still have a few of the young boys in there. We’re looking forward to this leg…it should be very interesting,” Feeney said.Ouma expressed his delight at making a return to the team and getting another chance to represent his country.“When it comes to the team’s performance it can always improve, the team is in a good place with both the experienced and the upcoming players blending well, it’s just taking it up a notch higher and firing from all cylinders,” he said.Kenya, currently 11th in the HSBC standings, was drawn in Pool B of the Los Angeles Sevens alongside South Africa, Series newcomers Ireland and Canada. All the other three sides are currently ranked above Kenya.The Los Angeles Sevens is scheduled to take place from February 29 to March 1 while the Vancouver Sevens will take place from March 7 to 8. Kenya’s squad for AWCON named Kenya 7s wins Africa Men’s Sevens to qualify for Tokyo 2020 Olympics Kenya 7s team aims to finish series on a high as focus shifts to Rio
Farmington Voice Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Pinterest (Opens in new window) The Harrison High community has planned a number of events and activities to commemorate the school’s legacy during its final year.The 49-year-old building is slated for closure in spring of 2019.Families, alumni, and staff are invited to participate in the following:Final homecoming weekend – September 21 and 22, 2018Friday evening activities include school tours and an auditorium presentation highlighting Harrison’s lauded history. Taligates and tours will precede the homecoming football game on Saturday at 1 p.m. against Stoney Creek on Buller Field. Harrison’s final homecoming dance will take place on Saturday evening in the gymnasium from 8 p.m. to 11 p.m.All classes are invited to hold their reunions and gatherings on this final homecoming weekend. Please contact Angela Leach, firstname.lastname@example.org, to make arrangements and have your class recognized.End of school year celebration – May 30 and June 1, 2019On Friday evening, an all-staff dinner will be held at Glen Oaks Country Club. For reservations or information, write to email@example.com. The entire community is invited to a June 1 closing event, with a memorabilia sale, closing ceremony, and alumni concert.Once a Hawk, Always a Hawk campaignSend your photo, holding a sheet of paper that shows when you graduated, what you are doing now, and the words “Once a Hawk, Always a Hawk,” to firstname.lastname@example.org, or by mail to Harrison High School Alumni Photos, 29995 W. 12 Mile Rd., Farmington Hills, MI 48334. Photos will be shared on an alumni wall.Stay informed by following facebook.com/hhshawklegacy. Legacy items, including t-shirts, hoodies and Coach Herrington bobbleheads, are available at Harrison’s main office or at cafepress.com/hhslegacy. Reported by
Anugerah yang dicapai Lion Air Group diberikan untuk kategori (Top 5 Airlines and Airline Groups by Passenger Carriage) dalam acara Penghargaan Bandar Udara Internasional Changi ke-14 (14th Changi Airline Awards). Dikutip dari siaran pers Lion Air (26/4), Ajang Changi Airline Awards 2019 diserahkan langsung Changi Airport Group (CAG) Chief Executive Officer (CEO), Mr. Lee Seow Hiang kepada Managing Director Lion Air Group, Capt. Daniel Putut Kuncoro Adi di Singapura.Penghargaan ini merupakan ketiga kali yang diterima Lion Air Group. Pada 2017 dan 2018 Lion Air Group telah memperoleh award serupa sejalan pengembangan empat perusahaan yaitu Lion Air, Batik Air dari Indonesia; Malindo Air dari Malaysia dan Thai Lion Air dari Thailand.Kehadiran Lion Air Group di Singapura untuk menjawab tingginya permintaan perjalanan udara selama ini serta sekaligus mempertegas kesungguhan Lion Air Group dalam memperluas konektivitas regional. Oleh karena itu, Lion Air sangat antusias terus mengembangkan network dari dan ke Changi. Dengan demikian, akan membawa lebih banyak pengunjung menuju ke tiga negara dimana Lion Air Group beroperasi dari Singapura.Singapura telah menempatkan salah satu bandar udara penghubung (hub) utama bagi konektivitas airlines dan travelers. Lion Air Group menantikan pertumbuhan berkelanjutan sehingga bisa membentuk dan melengkapi lalu lintas udara Singapura ke berbagai kota/ negara tujuan.Lion Air Group mengharapkan Bandara Changi akan semakin banyak membuka dan memberikan slot prime time untuk seluruh jaringan. Lion Air Group. Tujuan utama lebih memberikan kualitas penerbangan, tersedianya pilihan jadwal yang disesuaikan kebutuhan travelers serta dapat melakukan ekspansi dengan menambah rute baru menambah frekuensi terbang. Dengan bertambahnya kapasitas, Lion Air Group optimis dapat mendukung dalam meningkatkan investasi pada sektor ekonomi dan pariwisata di Singapura dengan Indonesia, Malaysia dan Thailand.Baca juga: Q1 2019, Lion Air Capai Level On Time Performance 85,97 Persen Frekuensi penerbangan Lion Air Group Lion AirSoekarno-Hatta – Singapura6 kali per hari Thai Lion AirDon Mueang – Singapura2 kali per hari Malindo AirKuala Lumpur – Singapura4 kali per hari Batik AirSoekarno-Hatta – Singapura3 kali per hari MaskapaiRuteFrekuensi Terbang Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading… RelatedLion Air Group Jadi 5 Maskapai Teratas Pembawa Penumpang Terbanyak ke Singapura08/05/2018In “Destinasi”Video Kasus Bagasi di Kualanamu Beredar, Lion Air Siap Tempuh Jalur Hukum02/08/2018In “Bandara”Terbang Perdana 15 Mei, Lion Air Gantikan Batik Air Layani Penerbangan ke Bandara YIA10/05/2019In “Bandara” Terminal 4 Bandara Internasional Changi Singapura (Mirror) Lion Air Group yang menaungi maskapai Lion Air, Batik Air, Malindo Air dan Thai Lion Aoir, baru saja mendapatkan penghargaan sebagai lima maskapai teratas yang paling banyak menyumbangkan penumpang di Bandara Internasional Changi, Singapura. Selama tahun 2018, Lion Air Group mengoperasikan 15 layanan penerbangan harian (regular flight) ke Changi dan telah mengangkut sekitar 1,4 juta penumpang. Lion Air Group mengoperasikan lebih dari 100 keberangkatan menuju Changi setiap minggunya.Baca juga: “Ogah Rugi, Cari Paling Murah dan Tidak Ada Pilihan,” Jadi Momok Pemumpang Pesawat di IndonesiaPergerakan tersebut melayani dari Bandar Udara Internasional Soekarno-Hatta, Tangerang (CGK): Lion Air enam kali sehari dan Batik Air tiga penerbangan harian; Thai Lion Air tiga penerbangan per hari dari Bandar Udara Internasional Don Mueang, Bangkok, Thailand (DMK) serta Malindo Air memiliki empat penerbangan setiap hari dari Bandar Udara Internasional Kuala Lumpur, Malaysia (KUL).
Related TopicsIndiansTrevor Bauer DETROIT—The Cleveland Indians take on the Detroit Tigers for a three-game weekend series. The Indians are currently 5-2 in the season series versus the Tigers. They also hold a four-game lead on the Tigers for the American League Central.The Indians are coming off a brief two-game sweep over the Milwaukee Brewers that helped the Indians improve their season record to 32-28.The Detroit Tigers are coming off a series in Boston where they only won the finale of a three-game series. The Tigers are 6-4 in their last 10 games. They have a record of 30-34.Here’s a preview of game one of a three-game set in Detroit:Time: 1:10 p.m.Starting Pitchers: RHP Trevor Bauer (4-4, 2.77 ERA) vs. RHP Michael Fulmer (2-5, 4.73 ERA)TV: SportsTime OhioOnline: MLB.TVRadio: WMMS 100.7, Indians Radio Network 3. Big lead for the bullpenUnless Trevor Bauer goes the distance, the Indians will need to have as big of a lead as possible. The bullpen is slowly returning to form. But still, the Indians know that no lead is safe right now— especially with no Andrew Miller. 1. Bauer OutageTrevor Bauer could use a solid start as he is coming off a loss to the Minnesota Twins. He went five and two-thirds innings, gave up six hits, three earned runs, three walks, and struck out 11 strikeouts. If his command is there early, odds are he will have a solid start. If not, he could be in for a long day at the office. For Bauer, it’s important for him to start to take off and get on a roll. 2. Get Fulmer deep in the countWhen Fulmer is ahead in the count, he has an ERA of 2.42. But when he is behind in the count, his ERA drops to 6.60. The Indians can also be successful by getting to Fulmer early on in the game. Once Fulmer gets going, he can become tough to beat. Tim Whelan
Legendary West Indies fast bowler Courtney Walsh has been appointed an assistant coach to the West Indies senior women’s team for the ongoing series against India Women.Walsh, who previously held the role of bowling coach with the Bangladesh senior men’s team, will assist interim head coach Gus Logie as the Windies Women play India Women in three ODI’s and five T20s.In August, Walsh had indicated to The Gleaner that he would relish a role in the West Indies setup, and the history-making fast bowler was happy when he was approached to work with his close friend Logie and impart his knowledge with the regional women. “My function is to focus a lot more on the bowlers and the cricket, in general, to get the ladies together. I’m just happy to be able to work with Gus – we haven’t had a chance to be on the same team since we were players and we just want the women to play the type of cricket we know they can play, said Walsh. Keen to remain Walsh, who also made it clear that he was keen to remain in the Caribbean to work following his Bangladesh stint, added that the transition to working with the women will be a smooth one. “The ladies have been very warm and receptive and listened to what I’ve got to say. They are not afraid of trying and implementing what I’ve been telling them. I think one of the advantages I have is that I was involved in women’s cricket before as a selector, and I was part of a couple of their training camps, so they know me and they’ve seen me around. They know I want the best for them and they appreciate that, so for me, it’s a plus coming back into the fold of the women’s team now,” Walsh added.Meanwhile, Jamaican physiotherapist Matthew Parchment will work alongside Walsh and Logie during the series. Parchment had recently worked with the Jamaica Scorpions and the Jamaica Tallawahs.
720p HD About Connatix V56892 1080p HD Tracey Claeys has reportedly been fired as Gophers head football coach. A meeting that included Athletic Director Mark Coyle and President Eric Kaler took place today where this decision was made.The Star Tribune and Fan Radio Network’s Mark Rosen were the first to report this story.The decision was made after Claeys publicly supported his players who boycotted the suspensions of 10 players. Those ten players were suspended for their involvement in an investigated sexual assault. None of those ten players were charged by law enforcement. 360p About Connatix V56892 1/1 Visit Advertiser website GO TO PAGE Skip Auto (360p) The Gophers had their best season this year under Claeys going 9-4 including a win in the Holiday Bowl last week.