Hormone signals that modulate feeding and exercise are in fact believed to be closely linked. Endurance running capacity in mammals, particularly humans, is thought to have evolved to maximize the chances of finding food. This study suggests that leptin plays a critical role both in regulating energy balance and encouraging behaviours that are “rewarding” for the person’s metabolism, i.e., engaging in physical activity to find food.The researchers studied voluntary wheel running in mice in cages. These mice can run up to seven kilometres a day. In a laboratory, the physical activity of normal mice was compared with that of mice who underwent a genetic modification to suppress a molecule activated by leptin, STAT3 (signal transducer and activator of transcription-3). The STAT3 molecule is found in the neurons that synthesize dopamine in the midbrain. This “mesolimbic dopaminergic pathway” is a like a motivational highway in the brain.“Mice that do not have the STAT3 molecule in the dopaminergic neurons run substantially more. Conversely, normal mice are less active because leptin then activates STAT3 in the dopamine neurons, signalling that energy reserves in the body are sufficient and that there is no need to get active and go looking for food”, explained Maria Fernanda Fernandes, first author of the study.And is leptin as important for motivation to be active in humans? Yes. “Previous studies have clearly shown a correlation between leptin and marathon run times. The lower leptin levels are, the better the performance. Our study on mice suggests that this molecule is also involved in the rewarding effects experienced when we do physical exercise. We speculate that for humans, low leptin levels increase motivation to exercise and make it easier to get a runner’s high”, summed up Stephanie Fulton.Mice, humans and mammals in general are thought to have evolved to increase the return on effective food acquisition behaviours. Ultimately, hormones are sending the brain a clear message: when food is scarce, it’s fun to run to chase some down. Pinterest Share on Twitter LinkedIn The joy of running. That sense of well-being, freedom and extra energy that runners often experience is not just a matter of endorphins. A study at the University of Montreal Hospital Research Centre (CRCHUM) shows that the “runner’s high” phenomenon is also caused by dopamine, an important neurotransmitter for motivation.“We discovered that the rewarding effects of endurance activity are modulated by leptin, a key hormone in metabolism. Leptin inhibits physical activity through dopamine neurons in the brain”, said Stephanie Fulton, a researcher at the CRCHUM and lead author of an article published today in the journal Cell Metabolism.Secreted by adipose tissue, leptin helps control the feeling of satiety. This hormone also influences physical activity. “The more fat there is, the more leptin there is and and the less we feel like eating. Our findings now show that this hormone also plays a vital role in motivation to run, which may be related to searching for food”, explained Stephanie Fulton, who is also a professor at Université de Montréal’s Department of Nutrition. Email Share Share on Facebook
Billionaire philanthropist David Rockefeller dies at age 101 Published: March 20, 2017 11:21 AM EDT NEW YORK (AP) David Rockefeller, the billionaire businessman and philanthropist who was the last in his generation of one of the country’s most famously philanthropic families, died Monday. He was 101.Rockefeller died in his sleep at his home in suburban Pocantico Hills, New York, according to his spokesman, Fraser P. Seitel.He was the youngest of six children born to John D. Rockefeller Jr. and the grandson of Standard Oil co-founder John D. Rockefeller. With the passing of his siblings, he became the guardian of his family’s fortune and head of a sprawling network of family interests, both business and philanthropic, that ranged from environmental conservation to the arts.To mark his 100th birthday in 2015, Rockefeller gave 1,000 acres of land next to a national park to the state of Maine.Aspects of the Rockefeller brothers’ upbringing became famous, including the 25-cent allowance, portions of which had to be set aside for charity and savings, and the inculcation that wealth brings great responsibility.Two of his brothers held elected office: Nelson Rockefeller served as the governor of New York, hungered for the White House and briefly served as vice president. Winthrop Rockefeller was a governor of Arkansas.David Rockefeller, however, wielded power and influence without ever seeking public office. Among his many accomplishments were spurring the project that led to the World Trade Center.And unlike his other brothers, John D. III and Laurance, who shied from the spotlight and were known for philanthropy, David Rockefeller embraced business and traveled and spoke widely as a champion of enlightened capitalism.“American capitalism has brought more benefits to more people than any other system in any part of the world at any time in history,” he said. “The problem is to see that the system is run as efficiently and as honestly as it can be.”Rockefeller graduated from Harvard in 1936 and received a doctorate in economics from the University of Chicago in 1940. He served in the Army during World War II, then began climbing the ranks of management at Chase Bank. That bank merged with The Manhattan Company in 1955.He was named Chase Manhattan’s president in 1961 and chairman and chief executive officer eight years later. He retired in 1981 at age 65 after a 35-year career.In his role of business statesman, Rockefeller preached capitalism at home and favored assisting economies abroad on grounds that bringing prosperity to the Third World would create customers for American products.He parted company with some of his fellow capitalists on income taxes, calling it unseemly to earn $1 million and then find ways to avoid paying taxes on it. He didn’t say how much he paid in taxes and never spoke publicly about his personal worth. In 2015, Forbes magazine estimated his fortune at $3 billion.As one of the Rockefeller grandchildren, David belonged to the last generation in which the inherited family billions were concentrated in a few hands. The next generation, known as “the cousins,” has more people.Rockefeller was estimated to have met more than 200 rulers in more than 100 countries during his lifetime, and often was treated as if he were a visiting head of state.Under Rockefeller, Chase was the first U.S. bank to open offices in the Soviet Union and China and, in 1974, the first to open an office in Egypt after the Suez crisis of 1956.In his early travels to South Africa, Rockefeller arranged clandestine meetings with several underground black leaders. “I find it terribly important to get overall impressions beyond those I get from businessmen,” he said.But Rockefeller took a lot of heat for his bank’s substantial dealings with South Africa’s white separatist regime and for helping the deposed, terminally ill Shah of Iran come to New York for medical treatment in 1979, the move that triggered the 13-month U.S. embassy hostage crisis in Tehran.Rockefeller maintained the family’s patronage of the arts, including its long-standing relationship with New York’s Museum of Modern Art, of which his mother had been a fervent patron. His private art collection was once valued at $500 million. The Rockefeller estate overlooking the Hudson River north of New York City is the repository of four generations of family history, including Nelson’s art and sculpture collection.One of the major efforts of Rockefeller’s later years was directed at restoring family influence in the landmark Rockefeller Center, most of which had been sold in the 1980s to Japanese investors. He eventually organized an investor group to buy back 45 percent of the property.His philanthropy and other activities earned him a Presidential Medal of Freedom, the nation’s highest civilian honor, in 1998.Rockefeller and his wife, the former Margaret McGrath, married in 1940 and had six children – David Jr., Richard, Abby, Neva, Margaret and Eileen. His wife, an active conservationist, died in 1996. SHARE Author: AP Do you see a typo or an error? Let us know.
COLOMBIA: During the course of a public hearing held on August 3, national infrastructure agency ANI declared the concession held by Ferrocarril del Pacífico SAS to have lapsed. The concession covers the upgrading, maintenance and operation of freight services on the Buenaventura — Cali, Cali — La Felisa and Zarzal — La Tebaida routes.According to ANI, FDP has failed to comply with the terms of the concession, with ‘serious’ infractions including the disposal of property without prior consent. The concessionaire has also allegedly failed to provide detailed monthly reports on progress with the upgrade programme.Under the terms of the ruling, the concessionaire would be liable to pay US$32∙8m in damages to the state for its failure to meet contract terms. ANI also notes that FDP has separately been fined US$275m for suspending freight services in 2016, a government inspection having revealed a failure to maintain track and structures to the required standards.A further hearing is due to be held at ANI headquarters in Bogotá on August 18 to consider the response from the concessionaire and its guarantors. Should the concession be wound up, assets and infrastructure would revert to the state. ANI would then work with local authorities and other parties to seek funding to tender a new concession, one that would ‘meet the current needs’ of freight customers while ensuring the ‘sustainability’ of the concession model.
LIVERPOOL, England (Reuters) – Liverpool forward Mohamed Salah’s virtuoso display in the 5-2 win over AS Roma on Tuesday brought his side to the brink of the Champions League final and posed a serious threat to Lionel Messi and Cristiano Ronaldo’s grip on the Ballon d’Or award.The Egyptian scored two brilliant goals in the first half against his former club to set Juergen Klopp’s side on their way to victory in the semi-final first leg at Anfield. He set up two more in the second half to cap a thrilling evening.Salah’s importance was further demonstrated by the fact Roma scored the two goals that give them a slither of hope of turning the tide around after he had been substituted.The Egyptian’s strikes brought him to a remarkable 43 goals in all competitions this season, keeping him at the front of the list of top scorers in Europe, one ahead of Real Madrid’s talisman Ronaldo and two ahead of Barcelona’s Messi.The Spain-based duo have had a stranglehold on the prestigious Ballon d’Or award since 2008, each winning the trophy for the world’s best player five times. But Salah’s decisive performances are threatening to break that hegemony.Since signing from Roma last season, the 25-year-old has already equalled the Premier League record for goals in a 38-game season with 31. He also recently pipped Kevin de Bruyne, Leroy Sane and David Silva of runaway champions Manchester City to the PFA Player-of-the-Year award.WORLD CLASS His manager Klopp encouraged reporters to stake Salah’s claim as the best in the world while admitting he faces serious competition.“If you think he’s the best in the world, write it or say it,” said Klopp.“He is in outstandingly good shape, in world-class shape, 100 percent. To be the best in the world you need to do that over a longer period, I think. There are a few others who are not too bad.”The Ballon d’Or has gone to a winner of the Champions League for the last four years and Liverpool may have to lift a sixth European Cup in Kiev if Salah is to usurp double holder Ronaldo, whose Real side face Bayern Munich in the other semi-final.Messi could also stake his claim to win the award for a sixth time with an influential performance for Argentina at the World Cup.But Salah will also be in Russia, the leading light of an Egypt team making their first appearance in the tournament for 28 years.If Salah leads Egypt out of Group A and steers them towards the quarter-finals, he will be able to make an even stronger case to prise the highly coveted individual award from the two greats of the game.
Daniel Jones, QB, Giants. Jones dazzled in his starting debut in Week 3, throwing for 336 yards, rushing for 28, and scoring four total touchdowns. Fantasy owners are having visions of Josh Allen — and Jones doesn’t have Golden Tate to throw to yet. Jones’s rushing ability should give him a decent floor most weeks, and with Saquon Barkley out for the next four-to-eight weeks, he should have the ball in his hands a lot. That will lead to some turnovers, but it should also lead to decent fantasy production. New York’s next four opponents are the Redskins, Vikings, Patriots, and Cardinals. You likely don’t want him for those middle games, but the bookends could yield big points.Wayne Gallman, RB, Giants. Gallman will be the No. 1 waiver claim this week because of Barkley’s injury. He showed some promise as a rookie in 2017, rushing for 476 yards (4.3 ypc), catching 34 passes for another 193 yards, and scoring once. It’s unclear if he’ll have the job to himself or if Elijhaa Penny (or some other soon-to-be-acquired RB) will eat into his touches, but Gallman should get first crack at the job. With Daniel Jones loosening up defenses, Gallman could produce, but the odds of getting anything more than FLEX production out of him is unlikely. That still might be enough to merit a No. 1 waiver claim with the byes coming up, but just know that Gallman could be fool’s good.Check out our full Week 4 waiver list for additional waiver pickups and free agent adds, including important handcuff RBs, WR3 fliers, and D/ST streamers. WEEK 4: Waiver pickups | FAAB planner | Trade values | Snap countsGuys like Hardman, Chark, Valdez-Scantling, and Dissly might already be owned in your league, which basically leaves Gallman and Jones as the highest priority waiver pickups. As we discuss below, Gallman might not amount to much while Barkley is out, but getting a “starting” RB for the next four-to-eight weeks is almost impossible to say no to. Jones is interesting because most owners don’t “need” a QB, but the dual-threat rookie could have major upside and be better than your current starter. It’s still early enough in the season that you should be able to move back up the waiver pecking order quickly if you use one this week, so don’t be afraid to be active.WEEK 4 NON-PPR RANKINGS:Quarterback | Running back | Wide receiver | Tight end | D/ST | KickerLISTEN TO THE SN FANTASY WEEK 4 PREVIEW PODCAST BELOWTop fantasy football waiver wire pickups and free agent adds for Week 4Unless otherwise noted, only players owned in fewer than 50 percent of Yahoo leagues considered.Taylor Gabriel, WR, Bears. Gabriel had been playing a lot of snaps through the first two weeks (close to 90 percent), but it resulted in just three catches and 35 yards (seven targets). That all changed on Monday night against the Redskins when undersized speedster caught six-of-seven targets for 75 yards and three TDs, including one-yard and three-yard scores. This will almost certainly be his best game of the season (and likely career), but Gabriel caught 67 passes for 688 yards (93 targets) and added another 61 yards on the ground last season. He scored just two touchdowns, but he had seven TDs in 13 games with the Falcons back in 2016, showing his big-play potential. You don’t want to use a waiver claim on a boom-or-bust receiver who just had his best game against a bad pass defense, but Gabriel is worth a free agent add. WEEK 4 DFS LINEUPS:DK cash | DK GPP | FD cash | FD GPP | Y! cash | Y! GPPPaul Richardson, WR, Redskins. Like Gabriel, Richardson had been playing a lot of snaps (around 83 percent), but aside from a short touchdown in Week 2, he hadn’t done much. But on Monday against the Bears, he caught all eight targets for 83 yards and a score. A good chunk of Richardson’s production came in the fourth quarter when the Redskins were trailing, but the speedy receiver has long shown fantasy promise. Many predicted a breakout in his first season in Washington last year, but injuries limited him to seven games. Terry McLaurin is receiving most of the atteneion in Washington, but Richardson isn’t far behind. He’s another worthwhile free agent add, especially with the Giants on tap for Week 4.MORE WEEK 4: Full waiver listWill Dissly, TE, Seahawks. Dissly has been producing over the past two weeks (11 catches, 12 targets, 1112 yards, three touchdowns), although his Week 2 score came in the definition of garbage time when he caught a touchdown on an untimed down with the Seahawks down by 12. Regardless, he’s clearly part of the offense, and he needs to be picked up given this week’s matchup. The Cardinals have been unbelievably bad against TEs this year (348 yards, five TDs), making Dissly a top Week 4 TE who’s available in 54 percent of Yahoo leagues.WEEK 4 PPR RANKINGS: Running back | Wide receiver | Tight end Last week started with DJ Chark scoring in a third game to open the season and ended with Terry McLaurin doing the same. In between, Mecole Hardman once again did an admirable Tyreek Hill impression while Daniel Jones and Kyle Allen both dominated in their first starts of the season. We also had a serious Saquon Barkley injury (ah, Wayne Gallman — we meet again), Taylor Gabriel’s three-TD quarter, and Will Dissly’s continued ascent up the TE rankings. So, yeah, the top Week 4 fantasy waiver wire pickups and free agent adds are gonna be pretty f’n weird. Even with only a handful of marquee names, there should be plenty of activity before and after waivers clear at around 4-5 a.m. ET on Wednesday in Yahoo and ESPN leagues.As injuries pile up and the bye weeks start, more and more fill-ins make our full free agent list. Backups like Zach Pascal (T.Y. Hilton), Mack Hollins (Alshon Jeffery and DeSean Jackson), and Darrel Williams (Damien Williams) could be in play this week depending on the status of the banged-up stars in front of them on their respective depth charts. Perhaps even more important are guys like Jamaal Williams, Marquez Valdes-Scantling, and Paul Richardson, who are quietly seeing upticks in workload. All are worthwhile free agent considerations if you have the roster space. The end of of the free agent list also has several potential D/ST streamers for Week 4, and if you need a new kicker, you can check out Week 4 kicker rankings or just smash buttons until someone random winds up on your team.
By The Nelson Daily SportsA pair of Nelson Selects Rep squads made the short trek across the 49th parallel to compete in the Coeur d’Alene Youth Soccer Tournament this past weekend.The Nelson U14 girl’s and U15 boy’s experienced mixed results at the two-day event.U14 Girl’s DivisionThe Nelson Selects found it very difficult to find goals in Coeur d’Alene, going scoreless in three games.“(Two games) Nelson dominated . . . but could not get the ball into the net,” said a team spokesperson.The Selects opened the tourney with a scoreless tie against Helena Arsenal of Idaho.Game two was against an impressive North Idaho Avalanche squad, consisting mostly of 15-year-old players.Nelson was definitely up against it against the Avs, losing 7-0.In game three, the Nelson defence turned up the tempo but the offence failed to produce once again as the Selects played to a scoreless tie against Sandpoint Strikers.U15 Boy’s DivisionThe Nelson Selects, coached by Scott Lewis, tied two and lost a 1-0 heartbreaker to finish out of the playoffs in the U16 Boy’s Division in Coeur d’Alene.The 1-0 loss came thanks to a controversial call by the referee, awarding the opposition a penalty shot.The week before in Trail, the Selects edged Cranbrook 2-1 to claim the top prize in the Kootenay South Tournament.Dylan Whiffen and Daniel Rodman scored for Nelson.The Selects advanced to the final by stopping host Kootenay South 1-0 and a much-improved Creston team email@example.com
Galway United host bottom club Limerick FC at Eamonn Deacy Park on Friday night at 7.45pm. The Super Blues are rejuvenated and one of the leagues form clubs at the moment, while Galway United will boosted by a crucial derby win against Sligo Rovers at Eamonn Deacy Park last week. When the sides met in Galway earlier in the season, United triumphed, winning 3-2 but Friday’s encounter will be another decisive fixture as both clubs bid to avoid the relegation places.TOMMY DUNNE: “WE HAVE TO BUILD SOME MOMENTUM”“The Sligo Rovers win was hugely important, it was timely. I don’t think many people gave us a chance against them. Anybody that watched the game will have noticed the resilience my players displayed. We’re still up for the fight and we will be eager to finish this season as strongly as possible. Some have written us off but we still believe in ourselves, in our abilities, and we’re willing to do the hard-work. We have to continue our form into the Limerick game and we need to build some momentum. Limerick will be another stern test for us. We know that they are the leagues form team along with Dundalk. They will be thinking they can come to Eamonn Deacy Park and turn us over but we have other ideas. We have to improve on our Sligo Rovers performance and continue to be clinical in-front of goal when the chances present themselves again. It’s another big game for us,” Dunne told www.galwayunitedfc.ieTEAM NEWSAlex Byrne (groin), Jason Molloy (thigh) and Padraic Cunningham (knee) remain on the sidelines for Galway United. Kilian Cantwell is also ruled out after he twisted his ankle against Sligo Rovers. Marc Ludden (knee) will undergo a late fitness test ahead of the Limerick game.REFEREEDavid McKeonGALWAY UNITED GOALSCORERSJake Keegan – 16 (12 league goals, 4 cup goals)Enda Curran – 12Padraic Cunningham – 7 (4 league goals, 3 cup goals)Gary Shanahan – 5 (3 league goals, 2 cup goals)Ryan Connolly – 3Jason Molloy – 1Samuel Oji – 1David O’Leary – 1Andy O’Connell – 1 (1 cup goal)FORM GUIDEGalway United – LWLLWLimerick – DWWDLLAST MEETING7/7/15 – Limerick 2-4 Galway Unitedprint WhatsApp Facebook Twitter Email
An injury time free from Man of the Match Padraig Commins sealed a first county U20 A football title for Claregalway yesterday in Duggan Park as his side defeated Salthill Knocknacarra 0-9 to 0-8. Tommy Devane reports: After the game Tommy spoke to Man of the Match Padraig Commins, who scored all nine points for Claregalway… Tommy also caught up with Claregalway manager John Kilmartin… print WhatsApp Facebook Twitter Email
Listen back to Ollie Turner and Kevin O’Dwyer from Kilmallock last Saturday as Oughterard booked their place in the All-Ireland Intermediate Club Football Final after a famous 1-12 to 0-12 win over Kerry side Templenoe. (Photo courtesy of Donal Kelly) print WhatsApp Facebook Twitter Email
[View the story “#Nextchat RECAP: Who’s Responsible for Workplace Wellness?” on Storify] On April 16, SHRM @WeKnowNext chatted with Robin Schooling (@RobinSchooling) about “Who’s Responsible for Workplace Wellness?”In case you missed it, here are all the informative tweets from the chat: